Tim,
You may want to open a Support ticket so they can work with you over the phone, but...
On the machines that are showing disconnected, can you go to:
C:\Windows\System32 (or SysWOW64)\ContegoSPOP and look at the spoplog.txt? Are there errors or any interesting messages?
Look at the spop.conf. Is the manager name/IP set correctly?
On the manager, if you SSH into the appliance, and then go to MANAGER and run a WATCHLOG, do you see errors or problems there?